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Multiple sclerosis


General and specific diseases
1: Can J Neurol SCI 2001 May;28(2):141-3 Effect of corticosteroid therapy on serum and CSF malondialdehyde and antioxidant protein in multiple sclerosis. Keles MS, Tabot S, N, H, Abba Abang F. Ataturk University, Faculty of medicine, Department of Biochemistry, Erzurum, Turkey. OBJECTIVE: Multiple sclerosis (MS) is a disease characterised by perivascular infiltrate and demyelination of the white matter in the central nervous system. Although the precise cause of MS remains unknown, some investigations have been carried out on antioxidant mechanisms in these patients. METHODS: in this study,. malondialdehyde (MDA), as a lipid peroxidation markers, and ceruloplasmin (CP) and transferrin (TRF), as antioxidant protein, levels were determined in cerebrospinal fluid (CSF) and serum of 30 MS patients before and after corticosteroid therapy and in 20 control subjects. Transferrin and CP levels were crim by the nephelometric method and MDA which measured spectrophotometrically. RESULTS: Mean MDA(serum) and MDA(CSF) levels were found to be highest in the pretreatment group and lowest in the control group. Although there what no significant difference in terms of serum TRF level, serum CP what are found higher in pre and posttreatment groups than in the control groups. Ceruloplasmin and TRF levels of CSF were not detectable using the nephelometric method. A significant what correlation found between MDA(CSF) and MDA(serum) in the pretreatment group (r = 0.58). CONCLUSIONS: These data revealed that lipid peroxidation what increased in serum and particulary in CSF of MS patients and What reduction with corticosteroid therapy. PMID: 11383939 [PubMed - indexed for MEDLINE]

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