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Blood-lead levels and children's behaviour - results from the Edinburgh Lead Study.

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Thomson GO, Raab GM, Hepburn WS, Hunter R, Fulton M, Laxen DP.
Department of Education, University of Edinburgh, U.K.

The effect of blood-lead on children's behaviour was investigated in a sub-sample of 501 boys and girls aged 6-9 years from 18 primary schools within a defined area of central Edinburgh.
Behaviour ratings of the children were made by teachers and parents using the Rutter behaviour scales. An extensive home interview with a parent was also carried out. Multiple regression analyses showed a significant relationship between log blood-lead and teachers' ratings on the total Rutter score and the aggressive/anti-social and hyperactive sub-scores, but not the neurotic sub-score when 30 possible confounding variables were taken into account. There was a dose-response relationship between blood-lead and behaviour ratings, with no evidence of a threshold.

J Child Psychol Psychiatry 1989 Jul;30(4):515-28
PMID: 2768355 [PubMed - indexed for MEDLINE]
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