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Attention deficit hyperactivity disorder, infantile autism, and elevated blood-lead: a possible relationship.


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Eppright TD, Sanfacon JA, Horwitz EA.
Deparment of Psychiatry and Neurology, University of Missouri-Columbia, 65212

This case involves a 4 1/2-year-old boy diagnosed with autism, attention deficit hyperactivity disorder (ADHD), and an elevated blood-lead level of 42 mcg/dl.
The child was treated for the elevated blood-lead with the chelating agent succimer. The parents reported a decrease in repetitive behaviors while on succimer with a regression to previous symptoms when medication was discontinued. Also seen was a decrease of hyperactive behavior while being treated with succimer.
This article explores the interaction and possible casual relationship of an elevated blood-lead, autism, and ADHD as well as treatment of the behavioral symptoms.

Mo Med 1996 Mar;93(3):136-8
PMID: 8867271 [PubMed - indexed for MEDLINE]
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